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Studies of signal transduction networks have provided important insights regarding the regulation of various cellular events, including cell proliferation, differentiation, development and regeneration. Signal transduction pathways detect extracellular signals at the cell surface and transmit them through the cytoplasm to nuclear and other intracellular targets. The mechanisms of intracellular signal transmission involve players that are conserved in organisms as diverse as nematodes and humans. In our laboratory, we are investigating the molecular mechanisms of signal transduction networks that control various biological regulatory systems in Caenorhabditis elegans and mammalian cultured cells.